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Quando doses de sildenafila foram administradas, conforme recomendação, em pacientes recebendo inibidores potentes do citocromo CYP3A4, a concentração plasmática máxima de sildenafila livre não foi superior a 200 nM em todos os indivíduos avaliados, e foram bem toleradas.

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In one embodiment, a fusion protein comprising a Tet repressor (TetR) from the Tc resistance operon of Escherichia coli transposon Tn10 fused to a transactivating domain (eg, that of VP16 from Herpes simplex virus) or a domain (eg, a dimerization domain) which recruits a transcriptional activator (eg, an endogenous transcriptional activator) to interact with the fusion protein by a protein-protein interaction (eg, a non-covalent interaction) is introduced into a cell. Increasingly, parents come out of meetings with school counselors, psychologists, psychiatrists et?

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